We’re excited to announce our latest work, now published in Frontiers in Molecular Biosciences! Through a collaboration with the Bagheri lab, we developed an agent-based computational testbed to explore how tunable CAR T-cell features and tumor properties impact solid tumor treatment. We adapted the Bagheri lab’s ARCADE framework to develop CAR T-cell Agent-based Representation of Cells And Dynamic Environments (CARCADE). This model enables one to explore how changing key tumor/treatment features impacts therapeutic efficacy, yielding hypotheses that correspond to various experimental equivalents. In this study, we validate the model, interrogate the biological underpinnings of various treatment outcomes, and propose novel tuned treatment strategies that can be tested experimentally. Congratulations to Alex and our excellent collaborators Dr. Jessica Yu and Dr. Neda Bagheri of the Bagheri lab! Check out the paper here, and access the CARCADE code freely on GitHub here!
