We’re excited to announce that our new study on predictive design of mammalian genetic programs is out in Science Advances! We paired engineered genetic parts that have special capabilities with computational models to design circuits that perform sophisticated, useful functions. We’re excited because this where synthetic biology is increasingly going: transitioning from construction based upon biophysical intuition to using predictive computational models to guide design of biological functions. Our approach enabled us to build a whole bunch of circuits executing digital logic and analog signal processing, integrating different mechanisms, and which worked as predicted at surprisingly high levels of complexity. We also showed how these circuits can be linked to other synthetic biology parts, including MESA biosensors, to build cells that sense and process environmental information in customized ways. Congrats to Joe, Viswajit, Amy, Patrick, Jon, and collaborator Dr. Neda Bagheri on this exciting work! Check out the new paper here! Additionally, check out the Northwestern Now press piece on the study here!
