We’re excited that SPORT, a computational protein design strategy for adjusting reconstitution propensity to fall into the sweet spot for your application, has officially been released in Nature Chemical Biology today. This Rosetta-based pipeline identifies mutations that tweak reconstitution propensity so that a split protein comes together only when needed – a property that is useful for creating protein-based sensors, biochemical assays, and parts for synthetic biology. Congratulations to Taylor, Jon, Will, Elizabeth, Alex, and our excellent and key collaborators Srivatsan Raman and Tony Meger on this fantastic effort! Check out our new paper here! Additionally, check out some press from Northwestern Engineering on the study here!
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