New paper: Developing, characterizing, and modeling CRISPR-based point-of-use pathogen diagnostics

We’re excited to share our recent work developing a nucleic acid sequence-based amplification pathogen diagnostic for SARS-CoV-2, with 20-200 aM sensitivity. We also develop an explanatory model to gain mechanistic insight into reaction performance. Congratulations to Dr. Katie Dreyer, Dr. Kate Dray, and our wonderful collaborators in the Lucks, Jewett, and Mangan groups. Check out the paper here!

New preprint: Developing, characterizing and modeling CRISPR-based point-of-use pathogen diagnostics

We’re excited to share our recent work developing a nucleic acid sequence-based amplification pathogen diagnostic for SARS-CoV-2, with 20-200 aM sensitivity. We also develop an explanatory model to gain mechanistic insight into reaction performance. Congratulations to Katie, Dr. Kate Dray, and our wonderful collaborators in the Lucks, Jewett, and Mangan groups. Check out the preprint here!

New paper: HaloTag display enables quantitative single-particle characterisation and functionalisation of engineered extracellular vesicles

We’re excited to announce our recent work developing a method using flexible HaloTag labeling to absolutely quantify surface protein loading at the individual EV level, providing new insights into EV heterogeneity. An interesting new insight is that existing methods can substantially underestimate surface display. Congratulations to Dr. Roxi Mitrut, Dr. Devin Stranford, and Beth. Check out the paper here!

New paper: Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions

We’re excited to share our recent collaboration with the Kamat Lab, exploring how lipid-protein interactions may be leveraged to direct proteins into extracellular vesicles. Congratulations Dr. Taylor Gunnels, Dr. Hailey Edelstein, and our excellent collaborators Dr. Justin Peruzzi and Dr. Neha Kamat of the Kamat Lab. Check out the paper here and the press piece here!