We’re excited to share our recent work discovering how structure influences synthetic receptor function—our lab’s first study using protein structure prediction! Congratulations to Will, Amparo, and Dr. Hailey Edelstein. Check out the preprint here!
Katie Dreyer successfully defends his Ph.D. dissertation. Congratulations, Dr. Dreyer!
New preprint: Engineered feedback employing natural hypoxia-responsive factors enhances synthetic hypoxia biosensors
We’re thrilled to share our recent work building improved hypoxia biosensors using genetic circuits, and improving understanding of the hypoxia response by developing a mathematical model for the biosensors. Congratulations to Katie, Dr. Patrick Donahue, and the rest of the team. Check out the preprint here!
New preprint: Developing, characterizing and modeling CRISPR-based point-of-use pathogen diagnostics
We’re excited to share our recent work developing a nucleic acid sequence-based amplification pathogen diagnostic for SARS-CoV-2, with 20-200 aM sensitivity. We also develop an explanatory model to gain mechanistic insight into reaction performance. Congratulations to Katie, Dr. Kate Dray, and our wonderful collaborators in the Lucks, Jewett, and Mangan groups. Check out the preprint here!
New paper: HaloTag display enables quantitative single-particle characterisation and functionalisation of engineered extracellular vesicles
We’re excited to announce our recent work developing a method using flexible HaloTag labeling to absolutely quantify surface protein loading at the individual EV level, providing new insights into EV heterogeneity. An interesting new insight is that existing methods can substantially underestimate surface display. Congratulations to Dr. Roxi Mitrut, Dr. Devin Stranford, and Beth. Check out the paper here!
New paper: Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
We’re excited to share our recent collaboration with the Kamat Lab, exploring how lipid-protein interactions may be leveraged to direct proteins into extracellular vesicles. Congratulations Dr. Taylor Gunnels, Dr. Hailey Edelstein, and our excellent collaborators Dr. Justin Peruzzi and Dr. Neha Kamat of the Kamat Lab. Check out the paper here!
Iva Hammitt-Kess successfully defends her MS dissertation. Congratulations, Iva!
Taylor Gunnels successfully defends his Ph.D. dissertation. Congratulations, Dr. Gunnels!
New paper: Building Synthetic Biosensors Using Red Blood Cell Proteins
We’re excited to share our recent work developing genetically-encoded biosensors for use in red blood cells and validating their function in living animals. Congratulations to Dr. Taylor Dolberg and Taylor Gunnels. Check out the paper here!
New preprint: Conversion of natural cytokine receptors into orthogonal synthetic biosensors
We’re excited to share our latest work in which we coopt naturally evolved receptor-ligand interactions and integrate them with self-contained signaling modules to build synthetic receptors that are well-suited to creating customized cellular therapies. Congratulations to Dr. Hailey Edelstein and Amparo. Check out the preprint here!